AI Article Synopsis
- The study investigates the expression of GLUT-1 in odontogenic lesions like OKC, DC, and AM to understand their metabolic behavior.
- The research analyzed 15 cases of each lesion type, focusing on the number of positive GLUT-1 cells, staining intensity, and expression patterns.
- Results indicated that OKC exhibited the highest GLUT-1 positivity and metabolic activity, compared to DC and AM, suggesting a significant difference in their biological behavior.
Article Abstract
Introduction: An array of odontogenic lesions manifest in the maxillofacial region with variable presentations. The biological behavior of lesions, such as odontogenic keratocyst (OKC), dentigerous cyst (DC), and ameloblastoma (AM) always invite debate. Glucose transporter 1 (GLUT-1) is proven to be an indicator of metabolic behavior of several benign and malignant neoplasms.
Aim: The purpose of this study was to evaluate the expression of GLUT-1 in OKC, DC, and AM to understand their metabolic behavior.
Materials And Methods: Immunohistochemical expression of GLUT-1 was evaluated in each of the 15 cases of OKC, DC, and AM. The number of labeled cells, staining intensity, and membrane or cytoplasmic expressions were the parameters assessed and analyzed using chi-square test.
Results: All cases showed positive GLUT-1 expression: 86.6% OKC showed more than 50% labeled cells followed by DC (40%) and AM (26.5%); 53.3% OKC showed strong intensity in comparison to AM, which showed weak intensity in 53.3% cases; 86.6% of OKCs showed both membrane and cytoplasmic expression followed by DC (40%) and AM (26.6%), whereas 73.3% of AM showed only membrane expression followed by DC (60%) and OKC (13.3%).
Conclusion: Odontogenic keratocyst was found out to be more metabolically active followed by DC and AM.
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| http://dx.doi.org/10.5005/jp-journals-10024-2048 | DOI Listing |
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