AI Article Synopsis
- Hypertension is a common issue during pregnancy, specifically characterized as Pregnancy Induced Hypertension (PIH), linked to changes in endothelial function and nitric oxide levels.
- Research aimed to investigate the role of reactive nitrogen species in PIH, comparing 60 patients with PIH to 60 without.
- The study found lower nitric oxide levels, higher S-nitrothiol levels, and decreased thiol levels in PIH patients, suggesting that nitrosative stress may play a key role in the development of PIH due to antioxidant depletion.
Article Abstract
Introduction: Hypertension is the most common medical problem encountered during pregnancy. Pregnancy Induced Hypertension (PIH) is also called a disease of maternal endothelium. Nitric-oxide being a potent vasodilator released by endothelial cells, its role has been implicated in PIH.
Aim: To study the role of reactive nitrogen species in PIH.
Materials And Methods: One hundred and twenty samples were selected for the study. Of these, 60 patients had PIH (case) and the rest without PIH (control). Estimation of serum nitric- oxide, serum nitrothiol, serum total thiol was done.
Results: The study showed decreased NOx (Mono nitrogen oxide No and No) levels in PIH as compared to control (p< 0.001). PIH patients had significantly higher levels of S-nitrothiols than control (p<0.01). Thiol levels were decreased in PIH as compared to control (p<0.001).
Conclusion: Thus, it is concluded from this study that nitrosative stress represents a point of convergence for several contributing factors potentially leading to the clinical manifestations of pregnancy induced hypertension. The antioxidants are used up while scavenging the free radicals.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427295 | PMC |
| http://dx.doi.org/10.7860/JCDR/2017/23960.9396 | DOI Listing |
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