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| http://dx.doi.org/10.1080/21645515.2017.1322442 | DOI Listing |
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Boosting Vaccine Research: The 16-Year Journey of TRANSVAC Vaccine Infrastructure.
Vaccines (Basel)
December 2024
European Vaccine Initiative (EVI), 69115 Heidelberg, Germany.
TRANSVAC represents a long-running effort to accelerate the development of novel vaccines by integrating institutions from across Europe under a single collaborative framework. This initiative has empowered the global vaccine community since 2009 including contributing toward the development and optimization of vaccine candidates as well as the provision of new adjuvants, research protocols, and technologies. Scientific services were provided in support of 88 different vaccine development projects, and 400 professionals attended TRANSVAC training events on various vaccine-related topics.
View Article and Find Full Text PDFAn assay for toxicity testing of type C β-toxin.
Front Immunol
April 2024
Department of Product Characterization and Formulation, Intravacc B.V., Bilthoven, Netherlands.
Introduction: Veterinary vaccines against type C need to be tested for absence of toxicity, as mandated by pharmacopoeias worldwide. This toxicity testing is required at multiple manufacturing steps and relies on outdated mouse tests that involve severe animal suffering. type C produces several toxins of which the β-toxin is the primary component responsible for causing disease.
View Article and Find Full Text PDFPotential business model for a European vaccine R&D infrastructure and its estimated socio-economic impact.
F1000Res
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Vaccine Formulation Institute (VFI), Plan-les-Ouates, Geneva, 1228, Switzerland.
Background: Research infrastructures are facilities or resources that have proven fundamental for supporting scientific research and innovation. However, they are also known to be very expensive in their establishment, operation and maintenance. As by far the biggest share of these costs is always borne by public funders, there is a strong interest and indeed a necessity to develop alternative business models for such infrastructures that allow them to function in a more sustainable manner that is less dependent on public financing.
View Article and Find Full Text PDFAutomated cell counting for Trypan blue-stained cell cultures using machine learning.
PLoS One
November 2023
Delft University of Technology, Delft, The Netherlands.
Cell counting is a vital practice in the maintenance and manipulation of cell cultures. It is a crucial aspect of assessing cell viability and determining proliferation rates, which are integral to maintaining the health and functionality of a culture. Additionally, it is critical for establishing the time of infection in bioreactors and monitoring cell culture response to targeted infection over time.
View Article and Find Full Text PDFAuthor Correction: A protocol for adding knowledge to Wikidata: aligning resources on human coronaviruses.
BMC Biol
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Department of Agrotechnology and Food Sciences, Laboratory of Systems and Synthetic Biology, Wageningen University & Research, Wageningen, The Netherlands.
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