AI Article Synopsis
- The study explored how transcranial electroanalgesia (TEA) works in rats and mice, focusing on the role of opioid mechanisms.
- Naloxone, an opioid blocker, was found to reverse the pain-relieving effects of TEA, indicating that these effects are opioid-dependent.
- Additionally, morphine-tolerant rats did not respond to TEA, but the presence of D-phenylalanine enhanced analgesia, suggesting that TEA activates the body's own opioid systems for pain relief.
Article Abstract
In partially restrained alert rats and mice, the opioid mechanism of the transcranial electroanalgesia was investigated. Naloxone (0.5-2.0 mg/kg) reversibly suppressed the electroanalgesia in rats. The electroanalgesic effect in rats tolerant to morphine in doses 5-10 mg/kg, was absent. The involvement of endogenous opioid mechanisms in electroanalgesia was confirmed by enhancing of the analgesia with D-phenylalanine (350 mg/kg). The findings suggest that analgesic effect is based on transcranial electrical stimulation of opioid mechanisms. Investigation of endogenous opioid mechanisms in different antinociceptive brain structures in experimental models of transcranial electroanalgesia, is discussed.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!