O-Methylmurrayamine A (7) and 7-methoxymurrayacine (8) are natural products isolated from Murraya koenigii and Murraya siamensis, respectively. In this paper, we report the synthesis of 7 and 8 which are featured in the key step of cyclization to form carbazole intermediate 5 with mild conditions. The structures were confirmed by H NMR, C NMR, and HR-ESI-MS. In addition, compounds 7 and 8 were tested for their neuroprotective effects against HO-induced PC12 cell damage. The results showed that compounds 7 and 8 have neuroprotective effect.
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| http://dx.doi.org/10.1080/10286020.2017.1327952 | DOI Listing |
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