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Conglomerated Imiquimod and Metronidazole Incorporated Biodegradable Nanofibrous Mats for Potential Therapy of Cervical Cancer.
Int J Nanomedicine
January 2025
Department of Mechanical Engineering, Chang Gung University, Taoyuan, 33302, Taiwan.
Background: In clinical practice, imiquimod is used to treat Human Papillomavirus (HPV)-related lesions, such as condyloma and Cervical Intraepithelial Neoplasia (CIN). Metronidazole is the most commonly prescribed antibiotic for bacterial vaginosis. The study developed biodegradable imiquimod- and metronidazole-loaded nanofibrous mats and assessed their effectiveness for the topical treatment of cervical cancer, a type of HPV-related lesion.
View Article and Find Full Text PDFHuman papillomavirus-associated cancers, precancers, and genital warts in Denmark, 2000-2022 - Current burden of disease and population impact of multi-cohort HPV vaccination.
Prev Med
December 2024
Unit of Virus, Lifestyle and Genes, Danish Cancer Institute, Strandboulevarden 49, 2100 Copenhagen O, Denmark; Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark; Department of Gynecology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen O, Denmark. Electronic address:
Article Synopsis
- The study analyzed cancer trends related to human papillomavirus (HPV) in Denmark from 2000 to 2022, focusing on cervical precancer, genital warts, and overall disease burden post-HPV vaccination.
- Findings revealed a significant decline in age-standardized incidence rates (ASRs) for cervical precancer and genital warts, particularly among women, while HPV-associated cancers have been rising in men and non-cervical sites among women.
- The conclusion emphasized that, even with vaccination efforts leading to decreased cases of certain HPV-related conditions, HPV-associated diseases continue to pose a public health challenge, especially among men.
Inadvertent Intrauterine Instillation of Trichloroacetic Acid During Sonohysterography.
Cureus
October 2024
Obstetrics and Gynecology, Crozer-Chester Medical Center, Upland, USA.
Trichloroacetic acid (TCAA) solution is used to treat vulvar condyloma and cervical intraepithelial neoplasia. Saline infusion sonohysterography (SIS) detects intrauterine pathology and fallopian tube patency in infertile patients. A 33-year-old Caucasian nulliparous fertility patient presented to the emergency department with extensive burns following accidental intrauterine instillation of TCAA during SIS with tubal perfusion.
View Article and Find Full Text PDFDisproportionate preponderance of HPV genotypes associated with anogenital warts among HIV-positive MSM.
Front Public Health
October 2024
Department of Dermatology and Venerology, Medical University of Innsbruck, Innsbruck, Austria.
Background: In this study, we characterized the HPV genotype distribution in a population of 489 adults already positive for HPV DNA. The study population was divided into two groups: 244 HIV-positive (HIV+) men who have sex with men (MSM) undergoing routine anal screening for sexually transmitted diseases (STDs) and 245 women undergoing routine cervical cancer screening. Acknowledging the fact that women and MSM represent two independent circles of sexual practices, which are-largely-exclusive of each other, we were interested in determining if particular genotypes of human papillomavirus (HPV) disproportionately predominate in one of these circles compared to the other.
View Article and Find Full Text PDFPhotodynamic Therapy for Condyloma Acuminatum and Cervical Intraepithelial Neoplasia Grade I in a Young Female Patient with Systemic Lupus Erythematosus: A Case Report.
Clin Cosmet Investig Dermatol
September 2024
Department of Dermatology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People's Republic of China.
Condyloma acuminatum (CA), commonly known as anogenital warts, is a prevalent sexually transmitted disease primarily caused by low risk human papillomavirus (HPV) types 6 and 11. This case report outlines the successful use of photodynamic therapy (PDT) to treat extensive condyloma acuminatum in a young female patient with systemic lupus erythematosus (SLE) undergoing immunosuppressive treatment. The patient also had cervical intraepithelial neoplasia grade I.
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