MCR-1 and OXA-48 Acquisition in KPC-Producing Escherichia coli after Colistin Treatment.

Antimicrob Agents Chemother

CHU Clermont-Ferrand, Laboratoire de Bactériologie Clinique, Clermont-Ferrand, France

Published: August 2017

The spread of -encoding plasmids into carbapenem-resistant raises concerns about the emergence of untreatable bacteria. We report the acquisition of in a carbapenem-resistant strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the carbapenemase-producing strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 -encoding plasmid. This is the first report of in carbapenemase-encoding bacteria in France.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527634PMC
http://dx.doi.org/10.1128/AAC.02540-16DOI Listing

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