AI Article Synopsis
- - Long-term sensitization (LTS) is linked to reduced feeding, which corresponds to a decrease in the excitability of the decision-making neuron B51.
- - Research focused on how Na and K channels affect B51's excitability showed that isolating Na channels during LTS training raised the firing threshold of B51 compared to untrained controls.
- - In contrast, isolating K channels did not display any notable differences in B51's activity between trained and untrained groups, indicating that Na channels play a key role in lowering B51 excitability during LTS.
Article Abstract
In , long-term sensitization (LTS) occurs concurrently with a suppression of feeding. At the cellular level, the suppression of feeding is accompanied by decreased excitability of decision-making neuron B51. We examined the contribution of voltage-gated Na and K channels to B51 decreased excitability. In a pharmacologically isolated Na channels environment, LTS training significantly increased B51 firing threshold, compared with untrained controls. Conversely, in a pharmacologically isolated K channels environment, no differences were observed between trained and untrained animals in either amplitude or area of B51 K-dependent depolarizations. These findings suggest that Na channels contribute to the decrease in B51 excitability induced by LTS training.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435880 | PMC |
| http://dx.doi.org/10.1101/lm.044883.116 | DOI Listing |
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