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Colistin resistance in ESBL- and Carbapenemase-producing Escherichia coli and Klebsiella pneumoniae clinical isolates in Cambodia.
J Glob Antimicrob Resist
September 2024
Medical Biology Laboratory, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
Objectives: Despite the critical importance of colistin as a last-resort antibiotic, limited studies have investigated colistin resistance in human infections in Cambodia. This study aimed to investigate the colistin resistance and its molecular determinants among Extended-spectrum beta-lactamase (ESBL)- and carbapenemase-producing (CP) Klebsiella pneumoniae (K. pneumoniae) and Escherichia coli (E.
View Article and Find Full Text PDFMobile Colistin-Resistant Genes , , and Identified in Diarrheal Pathogens among Infants, Children, and Adults in Bangladesh: Implications for the Future.
Antibiotics (Basel)
June 2024
Department of Microbiology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
Colistin is a last-resort antimicrobial for treating multidrug-resistant Gram-negative bacteria. Phenotypic colistin resistance is highly associated with plasmid-mediated mobile colistin resistance () genes. -bearing have been detected in many countries, with the emergence of colistin-resistant pathogens a global concern.
View Article and Find Full Text PDFDissemination of clinical Escherichia coli strains harboring mcr-1, bla and siderophore-producing plasmids in a Chinese hospital.
Antimicrob Resist Infect Control
June 2024
Department of Clinical Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Background: Carbapenem-resistant E. coli (CREco) pose a significant public health threat due to their multidrug resistance. Colistin is often a last-resort treatment against CREco; however, the emergence of colistin resistance gene mcr-1 complicates treatment options.
View Article and Find Full Text PDFAntimicrobial resistance profiles of Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae strains isolated from broiler chickens.
Food Microbiol
June 2024
Unit for Environmental Sciences and Management, North-West University, Potchefstroom, 2531, South Africa.
Globally, the spread of multidrug-resistant Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae from food to humans poses a severe threat to public health. The aim of this study was to assess the co-occurrence of colistin and β-lactamase resistance genes in E. coli, K.
View Article and Find Full Text PDFConvergence of plasmid-mediated Colistin and Tigecycline resistance in .
Front Microbiol
January 2024
Department of Clinical Laboratory, Ningbo No. 2 Hospital, Ningbo, China.
Objective: The co-occurrence of colistin and tigecycline resistance genes in poses a serious public health problem. This study aimed to characterize a strain, K82, co-harboring a colistin resistance gene (CoRG) and tigecycline resistance gene (TRG), and, importantly, investigate the genetic characteristics of the plasmid with CoRG or TRG in GenBank.
Methods: strain K82 was subjected to antimicrobial susceptibility testing, conjugation assay, and whole-genome sequencing (WGS).
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