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| http://dx.doi.org/10.1164/rccm.201608-1561LE | DOI Listing |
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The role of PCBP1 in carbon ion-induced ferroptosis and inhibition of lung adenocarcinoma proliferation.
Front Public Health
January 2025
School of Public Health, Gansu University of Chinese Medicine, Lanzhou, China.
Objective: To investigate the role of PCBP1 in the inhibition of lung adenocarcinoma proliferation by carbon irradiation.
Methods: A549 cells were irradiated with different doses of carbon ions to observe clonal survival and detect changes in cell proliferation. Whole transcriptome sequencing and the Illumina platform were used to analyze the differentially expressed genes in A549 cells after carbon ion irradiation.
Harnessing machine learning in contemporary tobacco research.
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Division of Molecular Medicine, Bose Institute, Kolkata 700054, India.
Machine learning (ML) has the potential to transform tobacco research and address the urgent public health crisis posed by tobacco use. Despite the well-documented health risks, cessation rates remain low. ML techniques offer innovative solutions by analyzing vast datasets to uncover patterns in smoking behavior, genetic predispositions, and effective cessation strategies.
View Article and Find Full Text PDFSurvival impact of immune-related adverse events in extensive stage small cell lung cancer patients: a retrospective cohort study.
Immunotherapy
January 2025
Department of Hematology & Oncology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Background: Prior research indicates a connection between immune-related adverse events (irAEs) and improved progression-free survival (PFS) and overall survival (OS) in non-small cell lung cancer. However, limited data exists for extensive stage small cell lung cancer (ES-SCLC).
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Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice.
Physiol Rep
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Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, USA.
The use of genetically diverse mouse models offers a more accurate reflection of human genetic variability, improving the translatability of findings to heterogeneous human populations. This approach is particularly valuable in understanding diverse immune responses to disease by environmental exposures. This study investigates the inflammatory responses to acute exposures to mainstream cigarette smoke (CS) and environmental tobacco smoke (ETS) in two genetically diverse mouse strains, CC002/UncJ (UNC) & Diversity Outbred (J:DO).
View Article and Find Full Text PDFDeep learning-based synthetic CT for dosimetric monitoring of combined conventional radiotherapy and lattice boost in large lung tumors.
Radiat Oncol
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Department of Radiotherapy, Changzhou Cancer Hospital, Honghe Road, Xinbei Area, Changzhou, 213032, China.
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