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The International Space Station Environment Triggers Molecular Responses in .
Front Microbiol
June 2022
Biotechnology and Planetary Protection Group, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, United States.
Due to immense phenotypic plasticity and adaptability, is a cosmopolitan fungus that thrives in versatile environments, including the International Space Station (ISS). This is the first report of genomic, proteomic, and metabolomic alterations observed in strain JSC-093350089 grown in a controlled experiment aboard the ISS. Whole-genome sequencing (WGS) revealed that ISS conditions, including microgravity and enhanced irradiation, triggered non-synonymous point mutations in specific regions, chromosomes VIII and XII of the JSC-093350089 genome when compared to the ground-grown control.
View Article and Find Full Text PDF[Formula: see text]There is a growing desire amongst space-faring nations to venture beyond the Van Allen radiation belts to a variety of intriguing locations in our inner solar system. Mars is the ultimate destination. In two decades, we hope to vicariously share in the adventure of an intrepid crew of international astronauts on the first voyage to the red planet.
View Article and Find Full Text PDFAeromedical retrieval for suspected appendicitis in rural and remote paediatric patients.
Australas J Ultrasound Med
February 2020
The Royal Flying Doctor Service 10/12 Brisbane Ave Barton Australian Capital Territory 2600 Australia.
Introduction: The aim of this paper was to describe the characteristics of paediatric patients who underwent an aeromedical retrieval within Australia (gender and Indigenous status) for suspected appendicitis between 1 July 2014 and 30 June 2018 (4 years). By understanding these trends, we hope to further justify the need for point-of-care ultrasound training for clinicians working in rural and remote Australia.
Method: Participants included Royal Flying Doctor Service (RFDS) patients aged 0-18 years (inclusive) who underwent an aeromedical retrieval for suspected appendicitis within Australia.
As Hopes Have Flown Before: Toward the Rational Design of Treatments for Alcohol Use Disorder.
Biol Psychiatry
June 2017
Yale University Department of Psychiatry, New Haven, Connecticut.
Bioprocessing in microgravity: applications of continuous flow electrophoresis to rat anterior pituitary particles.
J Biotechnol
June 1996
Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA.
In this report we describe the results of a continuous flow electrophoresis (CFE) experiment done on STS-65 in which we tested the idea that intracellular growth hormone (GH) particles contained in a cell lysate prepared from cultured rat anterior pituitary cells in microgravity might have different electrophoretic mobilities from those in a synchronous ground control cell lysate. Collectively, the results suggested that CFE processing in microgravity was better than on earth; more sample could be processed/time (6 x) and more variant forms of GH molecules could be resolved as well. We had also hoped to carry out a pituitary cell CFE experiment, but failure of the hardware required that the actual cell electrophoresis trials be done on earth shortly after Shuttle landing.
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