Caspase-2 triggers apoptosis, but how it is activated by different stimuli is unclear. In this issue, Ando et al. (2017. https://doi.org/10.1083/jcb.201608095) delineate two pathways of caspase-2 activation and show that, in response to DNA damage, caspase-2 forms a complex with the PIDDosome and NPM1 within the nucleolus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461038 | PMC |
| http://dx.doi.org/10.1083/jcb.201704114 | DOI Listing |
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