AI Article Synopsis
- The study investigates the prevalence of major depression among patients with liver disease related to Hepatitis B in China, finding a 6.4% rate of depression.
- Factors such as insomnia and global functioning were identified as significant predictors of major depression in these patients.
- Major depression negatively affects both physical and mental quality of life, highlighting the need for better identification and treatment strategies in this patient population.
Article Abstract
Background: There are no data about the frequency of major depression in patients with liver disease related to Hepatitis B virus (HBV) in China. This study examined the prevalence of major depression and its clinical correlates and association with quality of life (QOL) in patients with HBV-related liver diseases.
Method: Altogether 634 patients with HBV-related liver diseases met study entry criteria and completed the survey. The diagnosis of major depression was established with the Mini International Neuropsychiatric Interview (MINI). Socio-demographic and clinical characteristics, Global Assessment of Functioning (GAF) and QOL were measured.
Results: The prevalence of major depression was 6.4%. Multivariable logistic regression analyses revealed that insomnia (P=0.01, OR=5.5, 95%CI=1.4-21.6) and global functioning (P<0.001, OR=0.6, 95% CI=0.5-0.7) were independently associated with major depression. Major depression was associated with both poor physical (F =4.0, P=0.04) and mental QOL (F =26.2, P<0.001).
Conclusions: Given the negative impact of depression on patients' QOL, more attempts should be made to identify and treat it in HBV-related diseases.
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| http://dx.doi.org/10.1016/j.apnu.2017.02.004 | DOI Listing |
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