Three new indolediterpenoids, namely, 22-hydroxylshearinine F (), 6-hydroxylpaspalinine (), and 7--acetylemindole SB (), along with eight related known analogs (-), were isolated from the sea-anemone-derived fungus sp. AS-79. The structures and relative configurations of these compounds were determined by a detailed interpretation of the spectroscopic data, and their absolute configurations were determined by ECD calculations ( and ) and single-crystal X-ray diffraction (). Some of these compounds exhibited prominent activity against aquatic and human pathogenic microbes.
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