F-Fluoroform: a F-trifluoromethylating agent for the synthesis of SCFF-aromatic derivatives.

Herein the synthesis of various SCFF-containing derivatives is reported by a transition metal-free process. By using HCFF, readily generated from a bench-stable difluoromethyl sulfonium salt, various aromatic disulfides were easily converted into the desired radiolabelled trifluoromethylthiolated compounds in the presence of a base. This protocol allowed the formation of the SCFF-containing aromatic derivatives in good to excellent radiochemical yields. This process was also extended to the corresponding selenium derivative.