AI Article Synopsis
- * An 8-week treatment with NRG1 improved mitochondrial respiration related to complex 2 in the muscles of both diabetic mice and healthy controls, doubling the mitochondrial complex 2 subunit content.
- * The observed benefits of NRG1 on mitochondrial function may be linked to increased ERBB4 phosphorylation, without involving the usual signaling pathways like ERK1/2, AKT, or AMPK.
Article Abstract
It has been reported that neuregulin1 (NRG1) improves glucose tolerance in healthy and diabetic rodents. In vitro studies also suggest that NRG1 regulates myocyte oxidative capacity. To confirm this observation in vivo, we evaluated the effect on mitochondrial function of an 8-week treatment with NRG1 in db/db diabetic mice and C57BL/6JRJ healthy controls. NRG1 treatment improved complex 2-mediated mitochondrial respiration in the gastrocnemius of both control and diabetic mice and increased mitochondrial complex 2 subunit content by 2-fold. This effect was not associated with an increase in mitochondrial biogenesis markers. Enhanced ERBB4 phosphorylation could mediate NRG1 effects on mitochondrial function through signalling pathways, independently of ERK1/2, AKT or AMPK.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431817 | PMC |
| http://dx.doi.org/10.1038/s41598-017-02029-z | DOI Listing |
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