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Immune Dysregulation and Cellular Composition in Lichen Sclerosus Revealed by Integrative Epigenetic Analysis with Cell Type Deconvolution.
J Inflamm Res
January 2025
Key Laboratory of Biomechanics and Mechanobiology, Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Engineering Medicine, Beihang University, Beijing, 100191, People's Republic of China.
Background: Lichen sclerosus (LS) is a chronic inflammatory disease affecting skin and mucosal tissues, particularly external genitalia, with a risk of cancer. Its etiology is unknown, possibly involving immune dysregulation and inflammation.
Methods: Study used DNA methylation (DNAme) and single-cell RNA sequencing (scRNA-seq) to compare LS with normal skin.
Differences of simulated ankle dorsiflexion limitation on lower extremity biomechanics during long jump takeoff.
Heliyon
January 2025
Faculty of Sport Science, Ningbo University, Ningbo, 315211, China.
The long jump is an athletic event that demands speed, power, force application, and balance, with each phase being critical to overall performance. However, previous research has neglected the limiting effect of the wedge pedals on ankle dorsiflexion range of motion. This cross-sectional study investigated biomechanical changes in the lower extremities during long jumps under varying degrees of ankle dorsiflexion.
View Article and Find Full Text PDFBiomechanical Properties of Meniscal Repair Versus Meniscectomy for Horizontal Meniscal Tears: A Systematic Review.
Am J Sports Med
January 2025
Department of Orthopedic Surgery, Columbia University Irving Medical Center, New York, New York, USA.
Article Synopsis
- Limited biomechanical research explores how horizontal meniscus tears (HMTs), meniscal repair (MR), and meniscectomy affect knee biomechanics, prompting this systematic review to investigate changes in knee contact mechanics following these conditions.
- A total of 6 studies were analyzed, revealing that HMTs increase peak contact pressure (PCP) by 14.2% and decrease contact area (CA) by 7.1%; partial meniscectomies (PM) also raised PCP significantly while reducing CA, and complete meniscectomies (CM) resulted in even higher increases in PCP (54.5%).
- Meniscal repair (MR) showed no significant difference in PCP or CA compared to intact menisci, indicating that it
Time-of-day effects on physical performance and perceptual responses in Brazilian Jiu-Jitsu athletes.
Chronobiol Int
January 2025
Biomechanics Laboratory, Center of Sports, Federal University of Santa Catarina, Santa Catarina, Brazil.
This study investigated how the time of day affects physical performance and perceptual responses in Brazilian Jiu-Jitsu (BJJ) athletes. Given the significance of circadian rhythms on athletic capabilities, we aimed to determine whether performance variations occur across different times of the day (morning, 10:00-11:00h; afternoon, 14:00-15:00h; and evening, 18:00-19:00h) and if these effects differ by sex. In total, 23 BJJ athletes (9 females, 14 males) participated in this study.
View Article and Find Full Text PDFKnotless Versus Knotted Suture Anchors for Labral Repair of the Hip: A Systematic Review of Clinical and Biomechanical Outcomes.
Am J Sports Med
January 2025
Rothman Orthopaedic Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Background: Arthroscopic labral repair of the hip is successfully performed with increasing frequency using either knotless or knotted suture anchors, each with its own risks and benefits.
Purpose: To examine biomechanical and clinical outcomes for labral repair of the hip based on the use of knotted or knotless suture anchors.
Study Design: Systematic review; Level of evidence, 4.
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