AI Article Synopsis
- Pulmonary hypertension in neonates can occur alongside certain diseases and requires careful treatment approaches.
- Iloprost inhalation, a selective pulmonary vasodilator, poses challenges for mechanically ventilated infants, particularly during high-frequency ventilation.
- In a report on two patients, iloprost was well tolerated in a term neonate with congenital diaphragmatic hernia, but it caused significant blood pressure changes in a preterm infant, suggesting potential benefits for term infants with pulmonary hypertension.
Article Abstract
Pulmonary hypertension may coexist with certain diseases in neonates. Iloprost inhalation is one of the treatments which cause selective pulmonary vasodilatation. Inhalation is not an easy way of drug administration in mechanically ventilated infants; as some exhibit desaturations during inhalation. Moreover, inhalation of drug requires cessation of mechanical ventilation, if patient is on high frequency oscillatory ventilation. We presented two patients with pulmonary hypertension; term baby with congenital diaphragmatic hernia and preterm baby with respiratory distress syndrome; who had iloprost instillation during mechanical ventilation treatment. Iloprost instillation was well tolerated with no side effects in the term patient with diaphragmatic hernia; whereas severe blood pressure fluctuations were observed in the preterm infant. This report may courage administration of iloprost in term neonates with resistant pulmonary hypertension.
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