Age differences involving decision by description versus decision by experience were examined using the same general task structure to facilitate comparisons across decision types. Experiment 1 compared younger (19-43 years) and older (65-85 years) adults in four different experimental conditions involving a choice between a low-risk, low-return bet versus a high-risk, high-return bet. Experiment 2 compared young (18-27 years) to older (60-87 years) adults using similar experimental conditions, but with decisions involving a risky versus a certain option. Contrary to expectations, minimal differences were observed between ages in either study. Higher levels of ability and numeracy were associated with better performance and greater ability to benefit from experience, but the impact of these factors was not moderated by age. The results suggest that factors other than the simple distinction between decisions by description versus experience are necessary to characterize the nature of age effects in decision-making.
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http://dx.doi.org/10.1080/13825585.2017.1327014 | DOI Listing |
Pharmaceutics
January 2025
Department of Pharmaceutical Science, School of Pharmacy and Nutrition, University of Navarra, 31009 Pamplona, Spain.
Background/objectives: Colorectal cancer (CRC) holds the third and second position among cancers affecting men and women, respectively. Frequently, the first-line treatment for metastatic CRC consists of the intravenous administration of 5-fluorouracil and leucovorin in combination with oxaliplatin or irinotecan. Physiologically-based pharmacokinetic models (PBPK) aim to mechanistically incorporate body physiology and drug physicochemical attributes, enabling the description of both systemic and organ drug exposure based on the treatment specificities.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Nephrology and Dialysis, Sant'Anna Hospital, ASST Lariana, 22042 Como, Italy.
: Inflammation may contribute to hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) and is often present in patients with chronic kidney disease (CKD). Roxadustat is approved in multiple countries for the treatment of anemia of CKD. This pooled analysis evaluated the efficacy and safety of roxadustat in patients with dialysis-dependent (DD) or non-dialysis-dependent (NDD) CKD by inflammation status.
View Article and Find Full Text PDFDiagnostics (Basel)
January 2025
Department of Surgical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
: Colon cancer is one of the main causes of cancer-related mortality worldwide. Among its histopathological subtypes, mucinous adenocarcinoma (MAC) is characterized by a more aggressive behavior than non-mucinous adenocarcinoma (non-MAC). This study aimed to compare the clinical outcomes and postoperative recovery between MAC and non-MAC cases in order to better understand the treatment implications and optimize therapeutic strategies.
View Article and Find Full Text PDFDiagnostics (Basel)
January 2025
Department of Musculoskeletal Radiology, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain.
We aimed to analyze potential predictors for the development of metachronous fractures (MFs) after osteoporotic vertebral fractures (OVFs), with particular focus on radiological variables obtained at initial X-rays and computed tomography (CT) examinations, treatment applied (conservative management [CM] versus percutaneous vertebroplasty [PV]), and fractures located at the thoracolumbar junction (T11-L2). We conducted a two-center, observational retrospective study, including patients with single-level OVFs treated with CM or VP. We collected socio-demographic, radiological and treatment-related variables.
View Article and Find Full Text PDFDiagnostics (Basel)
January 2025
Elmhurst Hospital Center, Trauma Unit, Department of Surgery, NYC Health & Hospitals, New York, NY 11373, USA.
: Fluctuations in sodium levels (SLs) may increase mortality, severity, and prolonged length of stay (LOS) in critically ill patients. We aim to study the effect of SL on various clinical outcomes in patients with severe traumatic brain injury (TBI). : This is a single-center, retrospective study of patients with severe TBI from 1 January 2020 to 31 December 2023, inclusive.
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