AI Article Synopsis
- The study aimed to analyze the prevalence of various herpes viruses (HSV1, HSV2, CMV, VZV, HHV6) in a Swedish population aged 35 to 95 years, using serum samples from a population study.
- Results revealed high prevalence rates, particularly for HSV1 (79.4%) and CMV (83.2%); infections were more common in women and lower in younger birth cohorts.
- The findings suggest that women are more likely to carry herpes viruses, with a decreasing trend in HSV infections among more recent generations of adolescents and children.
Article Abstract
Background: Herpes viruses establish a life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe the seroepidemiology of Herpes simplex type 1 (HSV1), Herpes simplex type 2 (HSV2), Cytomegalovirus (CMV), Varicella Zoster virus (VZV) and Human herpes virus type 6 (HHV6) in an adult Swedish population (35-95 years of age).
Methods: Presence of antibodies against the respective viruses in serum from individuals in the Betula study was determined with an enzyme-linked immunosorbent assay (ELISA). Singular samples from 535 persons (53.9% women, mean age at inclusion 62.7 ± 14.4 years) collected 2003-2005 were analyzed for the five HHVs mentioned above. In addition, samples including follow-up samples collected 1988-2010 from 3,444 persons were analyzed for HSV.
Results: Prevalence of HSV1 was 79.4%, HSV2 12.9%, CMV 83.2%, VZV 97.9%, and HHV6 97.5%. Herpes virus infections were more common among women ( = 0.010) and a lower age-adjusted HSV seroprevalence was found in later birth cohorts ( < 0.001). The yearly incidence of HSV infection was estimated at 14.0/1000.
Conclusion: Women are more often seropositive for HHV, especially HSV2. Age-adjusted seroprevalence for HSV was lower in later birth cohorts indicating a decreasing childhood and adolescent risk of infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424393 | PMC |
| http://dx.doi.org/10.1186/s12979-017-0093-4 | DOI Listing |
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