Rationale: The pathway of Nontyphoid Salmonella meningitis, especially in exclusive breastfeeding infants, has not been well characterized.

Patient Concerns: We analyzed data related to nontyphoid Salmonella meningitis in 4 infants.

Diagnoses: No diarrhea was observed and the coproculture was negative for all patients.

Interventions: Early diagnosis and treatment with combination of third-generation cephalosporins plus quinolones for a minimum of 3 weeks is necessary to avoid severe sequelae and death.

Outcomes: The first 3 patients had a good evolution, whereas the last patient had multiple brain abscesses and hydrocephalus requiring treatment with a ventriculoperitoneal shunt.

Lessons: The highlights of our study are that all infants were exclusively breastfed, no diarrhea observed and the negative coproculture for all the 4 patients, which is relatively rare for Salmonella infection.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428575PMC
http://dx.doi.org/10.1097/MD.0000000000006665DOI Listing

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