In this work, we present the combination of microfluidic chips and mass spectrometry employing laser-induced liquid beam ionization/desorption. The developed system was evaluated with respect to stable beam generation and laser parameters as well as solvent compatibility. The device was exemplarily applied to study a vinylogous Mannich reaction performed in continuous flow on chip. Fast processes can be observed with this technique which in the future could be beneficial for studying intermediates or contribute to the elucidation of reaction mechanisms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.analchem.7b01026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Stripe Noise Removal in Blazed Grating Generation for Electrically Tunable Beam Deflector.
Materials (Basel)
January 2025
Department of Information Display, Kyung Hee University, Seoul 02447, Republic of Korea.
In this paper, we demonstrate a blazed phase grating to achieve tunable beam steering and propose a novel algorithm to reduce the stripe noise in wrapped phase. To control the diffraction angle to steer light to the desired direction, an electrically tunable transmission-type beam deflector based on liquid crystals is introduced, and electric fields are applied to the patterned indium tin oxide electrodes to change its phase retardation. Two different 2π phase-wrapping methods are applied to obtain various diffraction angles within the minimum cell-gap, and the method of equal interval of phase achieves a worthwhile diffraction efficiency compared to the methods based on equal interval of diffraction angle.
View Article and Find Full Text PDFStable laser-acceleration of high-flux proton beams with plasma collimation.
Nat Commun
January 2025
School of Mathematics and Physics, Queen's University Belfast, Belfast, UK.
Laser-plasma acceleration of protons offers a compact, ultra-fast alternative to conventional acceleration techniques, and is being widely pursued for potential applications in medicine, industry and fundamental science. Creating a stable, collimated beam of protons at high repetition rates presents a key challenge. Here, we demonstrate the generation of multi-MeV proton beams from a fast-replenishing ambient-temperature liquid sheet.
View Article and Find Full Text PDFInsights into Calcium Phosphate Formation Induced by the Dissolution of 45S5 Bioactive Glass.
ACS Biomater Sci Eng
January 2025
CEA, DES, ISEC, DPME, SEME, University of Montpellier, Marcoule, Bagnols-sur-Cèze F-30207, France.
Although models have been proposed to explain the mechanisms of bioglass (BG) dissolution and subsequent calcium phosphate (CaP) mineralization, open questions remain. The processes in which phase transition occurs in aqueous solutions and their dynamics remain underexplored partly because traditional instruments/techniques do not allow for direct observations at the adequate time and length scales at which such phase transformations occur. For instance, given the crucial role of the silica gel in CaP formation during BG dissolution, uncertainty exists about how such a silica gel forms on the BG surface.
View Article and Find Full Text PDFFor Omphalotus japonicus, the coloring molecule was found and characterized using a simple method of identification with a color reaction. The compound that chang color under basic conditions was isolated from a methanolic extract of O. japonicus by liquid-liquid extraction.
View Article and Find Full Text PDFPolarization resolved second harmonic scattering of neat water in the right angle and forward scattering geometries.
J Chem Phys
January 2025
Institut Lumière Matière, Université de Lyon, UMR 5306 CNRS, Université Claude Bernard Lyon 1, 69622 cedex Villeurbanne, France.
Liquid water still remains an ubiquitous liquid whose molecular organization requires careful investigation. In this work, we present a study of the second harmonic scattering (SHS) intensity for two different scattering angles, namely, the forward and the right angle geometries. This method performed at optical wavelengths is indeed selective toward long correlation lengths.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!