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Ultrasensitive bioanalysis: current status and future trends. | LitMetric

Ultrasensitive bioanalysis: current status and future trends.

Bioanalysis

Service de Pharmacologie et Immunoanalyse (SPI), CEA, INRA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.

Published: May 2017

AI Article Synopsis

Article Abstract

Ligand-binding techniques such as immunoassays, the reference for clinical diagnosis, offer a wide range of innovative approaches based on signal DNA amplification, nanotechnologies or digital assays, which result in technologies with sensitivities more than 1000-times that of formats used 20 years ago. Providing that these technologies gain acceptance and translate into robust commercial platforms, we expect that several fields will be impacted in the near future, including the clinical diagnosis of cancer markers, the early detection of infectious diseases and the safety of biotherapeutics. Furthermore, the combination of these techniques with microfluidic systems will allow probing of biological diversity at the single cell level and will lead to the discovery of novel and rare biomarkers.

Download full-text PDF

Source
http://dx.doi.org/10.4155/bio-2017-0018DOI Listing

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