Background: Quorum sensing is the key regulator of virulence factors of such as biofilm formation, motility, productions of proteases, hemolysin, pyocyanin, and toxins. The aim of this study was to explore the effect of the extracts from some medicinal plants on quorum sensing and related virulence factors of .
Material And Methods: Quorum sensing inhibitory (OSI) effect of the alcohol extracts of 20 medicinal plants was evaluated by reporter using agar cup diffusion method. The efficient QSI extracts were tested for their activity against biofilm synthesis, motility, and synthesis of pyocyanin from PA14.
Results: The extracts of , and exhibited potent quorum quenching effect. On the other hand, and extracts showed lower QSI activity. These extracts exhibited significant elimination of pyocyanin formation and biofilm development of PA14. In addition, they significantly inhibited twitching and swimming motilities of PA14.
Conclusion: This study illustrated, for the first time, the importance of , and as quorum sensing inhibitors and virulence suppressors of . Thus, these plants could provide a natural source for the elimination of pathogenesis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416647 | PMC |
| http://dx.doi.org/10.21010/ajtcam.v13i5.10 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!