Stopping chromosomes from breaking bad.

Elife

Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, United States.

Published: May 2017

AI Article Synopsis

  • The scaffolding structure is crucial for keeping chromosome pairs intact during cell division.
  • It helps prevent double-strand breaks, which can lead to genetic instability.
  • Understanding this mechanism is important for studying DNA repair and cancer biology.

Article Abstract

The scaffolding that holds chromosome pairs together plays a key role in limiting the levels of double-strand breaks.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423766PMC
http://dx.doi.org/10.7554/eLife.27292DOI Listing

Publication Analysis

Top Keywords

stopping chromosomes
4
chromosomes breaking
4
breaking bad
4
bad scaffolding
4
scaffolding holds
4
holds chromosome
4
chromosome pairs
4
pairs plays
4
plays key
4
key role
4

Similar Publications

Chromosome movement speeds during anaphase are regulated by depolymerization of microtubules. Several models describe chromosome movement during cell division but none of them consider post-translational modifications of tubulin, even though such modifications help specify microtubules for unique cellular activities. Among these modifications, acetylation of Lysine 40 is one of the common post-translational modifications.

View Article and Find Full Text PDF

Embryo development is stimulated by calcium (Ca) signals that are generated in the egg cytoplasm by the fertilizing sperm. Eggs are formed via oogenesis. They go through a cell division known as meiosis, during which their diploid chromosome number is halved and new genetic combinations are created by crossing over.

View Article and Find Full Text PDF
Article Synopsis
  • The cohesin protein complex helps organize chromosomes into specific domains but its biological importance is unclear.
  • This study highlights that cohesin is essential for the differentiation and function of dendritic cells, particularly in antigen presentation and IL-12 secretion.
  • It also shows that the interplay between cohesin and the transcription factor IRF8 influences chromatin structure, gene expression, and the activation of dendritic cells.
View Article and Find Full Text PDF

The Philadelphia (Ph) chromosome is one of the few genetic aberrations in which a casualty has been proven, and as such represents a success in the history of medicine. This is also evident in the setting of Ph+ acute lymphoblastic leukemia (Ph+ ALL), the most frequent genetic subgroup in adult ALL, whose incidence increases with age and whose prognosis, prior to the advent of tyrosine kinase inhibitors (TKIs), was particularly poor. The outcome and management of Ph+ ALL patients have greatly improved since the incorporation of 1st, 2nd and 3rd generations TKIs in the therapeutic backbone, and is further changing with the more recent introduction of immunotherapy.

View Article and Find Full Text PDF
Article Synopsis
  • Lenalidomide (LEN) can help 60-70% of patients with del(5q) myelodysplastic neoplasm achieve independence from red blood cell transfusions (RBC-TI), but there's a concern about its toxicity and cost.
  • The HARMONY Alliance study followed 118 low-intermediate risk MDS patients who discontinued LEN, finding that 50 lost RBC-TI after a median of 49 months.
  • Factors like having a low transfusion burden before treatment, completing at least 12 LEN cycles, being younger, and having higher hemoglobin levels at withdrawal were linked to longer RBC-TI duration after discontinuing LEN.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!