The scaffolding that holds chromosome pairs together plays a key role in limiting the levels of double-strand breaks.
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http://dx.doi.org/10.7554/eLife.27292 | DOI Listing |
PLoS One
December 2024
Biology Department, York University, North York, Ontario, Canada.
Chromosome movement speeds during anaphase are regulated by depolymerization of microtubules. Several models describe chromosome movement during cell division but none of them consider post-translational modifications of tubulin, even though such modifications help specify microtubules for unique cellular activities. Among these modifications, acetylation of Lysine 40 is one of the common post-translational modifications.
View Article and Find Full Text PDFFront Cell Dev Biol
September 2024
Department of Animal Sciences Purdue University West Lafayette, West Lafayette, IN, United States.
Embryo development is stimulated by calcium (Ca) signals that are generated in the egg cytoplasm by the fertilizing sperm. Eggs are formed via oogenesis. They go through a cell division known as meiosis, during which their diploid chromosome number is halved and new genetic combinations are created by crossing over.
View Article and Find Full Text PDFbioRxiv
October 2024
Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Blood
August 2024
Hematology, Sapienza University of Rome, Rome, Italy.
The Philadelphia (Ph) chromosome is one of the few genetic aberrations in which a casualty has been proven, and as such represents a success in the history of medicine. This is also evident in the setting of Ph+ acute lymphoblastic leukemia (Ph+ ALL), the most frequent genetic subgroup in adult ALL, whose incidence increases with age and whose prognosis, prior to the advent of tyrosine kinase inhibitors (TKIs), was particularly poor. The outcome and management of Ph+ ALL patients have greatly improved since the incorporation of 1st, 2nd and 3rd generations TKIs in the therapeutic backbone, and is further changing with the more recent introduction of immunotherapy.
View Article and Find Full Text PDFLeukemia
October 2024
Fondazione Sindromi Mielodisplastiche FISiM-ETS, Bologna, Italy.
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