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Effects of substitute coated with hyaluronic acid or poly-lactic acid on implant fixation: Experimental study in ovariectomized and glucocorticoid-treated sheep. | LitMetric

Effects of substitute coated with hyaluronic acid or poly-lactic acid on implant fixation: Experimental study in ovariectomized and glucocorticoid-treated sheep.

J Tissue Eng Regen Med

Orthopaedic Research Laboratory, Department of Orthopaedic Surgery and Traumatology O, Odense University Hospital, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Published: February 2018

AI Article Synopsis

  • The study assesses the effectiveness of hyaluronic acid (HyA) and poly-lactic acid (PDLLA) coatings on hydroxyapatite (HA) and β-tricalcium phosphate (βTCP) scaffolds for improving bone implant fixation in sheep with weakened bones.
  • Results show that bone formation around implants coated with HyA and PDLLA is not significantly different from traditional allografts, but pure HA/βTCP alone results in less bone formation.
  • The findings suggest that HyA and PDLLA enhance the osteoconductive properties of bone substitutes, making them promising new materials for improving implant integration in compromised bone conditions.

Article Abstract

Investigated in healthy animal models, hyaluronic acid (HyA) and poly- -lactic acid (PDLLA) demonstrate osteoconductive properties when coated onto hydroxyapatite (HA) and β-tricalcium phosphate (βTCP) scaffolds. In this study, we examined the efficacy of HA/βTCP granules coated with HyA or PDLLA on implant fixation when applied as graft materials in 2-mm size defects created in the femur condyles of ovariectomized (OVX) glucocorticoid-treated (GC) sheep. Titanium alloys were inserted into the femur condyles of OVX and GC-treated sheep, and the concentric gaps were filled with either allograft obtained from a healthy donor sheep (control), pure HA/βTCP, HA/βTCP-HyA or HA/βTCP-PDLLA. After 12 weeks, the bone formation adjacent to the implant surface was evaluated by histology and histomorphometry, while the implant fixation was measured by a push-out test. The investigation showed a bone formation in the HA/βTCP-HyA and HA/βTCP-PDLLA groups not significantly different from allograft (p  >  0.05), whereas the HA/βTCP group revealed a significantly reduced formation of bone compared with allograft (p  <  0.05). Bone-implant contact (BIC) and mechanical properties were similar comparing HA/βTCP-HyA and HA/βTCP-PDLLA with allograft (p  >  0.05). This study demonstrated that bone substitutes infiltrated with PDLLA and HyA possess osteoconductive properties comparable to allograft when tested in sheep with an OVX and GC-induced bone loss. With no significant difference in implant fixation and bone formation, HyA and PDDLA are indeed considered valuable as new coating materials for composite ceramics when tested in a sheep model - even in bones of a compromised quality.

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Source
http://dx.doi.org/10.1002/term.2447DOI Listing

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