Exophytic pontine glioblastoma multiforme (GBM) is a highly malignant tumor of posterior fossa, which is quite rare and such tumor presenting as cerebellopontine (CP) angle mass is even rarer. Here, we describe a 12-year-old boy who presented with imbalance on walking and facial nerve paresis. Magnetic resonance imaging of the brain revealed an irregular ring enhancing mass lesion of the CP angle, which was initially thought to be a tuberculoma, but was later confirmed to be a GBM. Clinical and radiological differentiation of uncommon lesions of CP angle in children is discussed with brief review of pertaining literature.
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http://dx.doi.org/10.4103/1793-5482.148801 | DOI Listing |
Childs Nerv Syst
December 2024
Department Neuropathology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, 560029, India.
Introduction: Diffuse intrinsic pontine glioma (DIPG) in children comprises 80% of brainstem gliomas. In 2021, 5th edition of WHO CNS tumor classification defined H3K27M altered diffuse midline gliomas (DMGs) which replaced this entity. Lesion location precludes resection and the only current option available is radiotherapy.
View Article and Find Full Text PDFChilds Nerv Syst
April 2024
Department of Pediatrics, Gynecology and Obstetrics, Division of General Pediatrics, Pediatric Hematology and Oncology Unit, University Hospitals of Geneva, Geneva, Switzerland.
Purpose: Brain stem tumors in children < 3 months at diagnosis are extremely rare. Our aim is to study a retrospective cohort to improve the understanding of the disease course and guide patient management.
Methods: This is a multicenter retrospective analysis across the European Society for Pediatric Oncology SIOP-E HGG/DIPG Working Group linked centers, including patients with a brainstem tumor diagnosed between 2009 and 2020 and aged < 3 months at diagnosis.
World Neurosurg
April 2024
Department of Neurological Surgery, St. John's Neuroscience Institute, Tulsa, Oklahoma, USA. Electronic address:
With improvements in anesthesia, monitoring, and peroperative care, the surgical removal of intrinsic brainstem pathology has become a possibility. Although surgical removal of deep-seated lesions continues to have significant morbidity, at least temporarily, associated with it, removal of exophytic lesions can be accomplished with little disability for the patient. The key to a good outcome, when removing cerebral cavernous malformation, is preservation of adjacent neurovascular bundles, use of sharp dissection over blunt pulling, judicious use of cautery in and around the brainstem, and preservation of the developmental venous anomaly, when present.
View Article and Find Full Text PDFObjective: Safe entry zones (SEZs) enable safe tissue transgression to lesions beneath the brainstem surface. However, evidence for the safety of SEZs is scarce and is based on anatomical studies, case reports, and small series.
Methods: A cohort of 154 patients who underwent microsurgical brainstem cavernous malformation (BSCM) treatment during a 23-year period and who had preoperative MR images and intraoperative photographs or videos was retrospectively examined.
Neuro Oncol
May 2022
Department of Radiology and Medical Imaging, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
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