AI Article Synopsis
Article Abstract
Our understanding of development and function of natural killer (NK) cells has progressed significantly in recent years. However, exactly how uterine NK (uNK) cells develop and function is still unclear. To help investigators that are beginning to study tissue NK cells, we summarize in this review our current knowledge of the development and function of uNK cells, and what is yet to be elucidated. We compare and contrast the biology of human and mouse uNK cells in the broader context of the biology of innate lymphoid cells and with reference to peripheral NK cells. We also review how uNK cells may regulate trophoblast invasion and uterine spiral arterial remodeling in human and murine pregnancy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402472 | PMC |
| http://dx.doi.org/10.3389/fimmu.2017.00467 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Expression of NKp46 and other activating inhibitory receptors on uterine endometrial NK cells in females with various reproductive failures: A review.
Reprod Med Biol
January 2025
Department of Obstetrics and Gynecology School of Medicine, Hyogo Medical University Nishinomiya Hyogo Japan.
Background: Uterine endometrial natural killer (uNK) cells represent major leukocytes in the mid-secretory phase of the cell cycle, and their number is further increased during early pregnancy. The activating and inhibitory receptors expressed on their surface mediate various functions of uNK cells, such as cytotoxicity, cytokine production, spiral artery remodeling, and self-recognition.
Methods: This study reviewed the most recent information (PubMed database, 175 articles included) regarding the activating and inhibitory receptors on uNK cells in human females with healthy pregnancies and the evidence indicating their significance in various reproductive failures.
Impact of antiphospholipid syndrome on placenta and uterine NK cell function: insights from a mouse model.
Sci Rep
December 2024
Laboratory of Molecular and Cellular Immunology, Institute of Molecular Biology NAS RA, 7 Hasratyan Str., Yerevan, 0014, Armenia.
Antiphospholipid syndrome (APS) is associated with recurrent pregnancy morbidity, yet the underlying mechanisms remain elusive. We performed multifaceted characterization of the biological and transcriptomic signatures of mouse placenta and uterine natural killer (uNK) cells in APS. Histological analysis of APS placentas unveiled placental abnormalities, including disturbed angiogenesis, occasional necrotic areas, fibrin deposition, and nucleated red blood cell enrichment.
View Article and Find Full Text PDFTissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus.
Mucosal Immunol
December 2024
Microbiology and Immunology Department, Loyola University Health Science Campus, Maywood, IL, United States 60153. Electronic address:
The murine uterus contains three subsets of innate lymphoid cells (ILCs). Innate lymphoid cell type 1 (ILC1) and conventional natural killer (cNK) cells seed the uterus before puberty. Tissue-resident NK (trNK) cells emerge at puberty and vary in number during the estrous cycle.
View Article and Find Full Text PDFTreg cells promote decidual vascular remodeling and modulate uterine NK cells in pregnant mice.
JCI Insight
December 2024
Robinson Research Institute and School of Biomedicine, The University of Adelaide, Adelaide, South Australia, Australia.
Article Synopsis
- Regulatory T (Treg) cells are crucial for maintaining immune tolerance during pregnancy, ensuring that the mother’s body accepts the developing fetus and placenta.
- In a study using a specific mouse model, researchers found that depleting Treg cells early in pregnancy led to problems with the remodeling of uterine arteries, reduced natural killer (uNK) cell numbers, and resulted in fetal loss and growth restriction.
- By transferring Treg cells from healthy donors, the negative effects on vascular function and fetal health were mitigated, highlighting the important role Treg cells play in adapting the uterine environment for a successful pregnancy and their connection to issues like preeclampsia.
Exploring the management of recurrent angioedema caused by different mechanisms.
Curr Opin Allergy Clin Immunol
February 2025
Department of Medicine and Medical Specialties, A. Cardarelli Hospital, Naples, Italy.
Purpose Of Review: We aim to explore the most recent insights into the pathogenesis of recurrent angioedema caused by different mechanisms and then focus on the management and treatment approaches available.
Recent Findings: The recently developed DANCE consensus classification identifies five types of angioedema: mast cell-mediated (AE-MC), bradykinin-mediated, because of intrinsic vascular endothelium dysfunction (AE-VE), drug-induced (AE-DI), and due to unknown mechanisms (AE-UNK). These subtypes require different management with treatment choices targeting the main pathogenetic pathways involved in each form.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!