AI Article Synopsis
- The Torque teno canis virus (TTCaV) is a small virus affecting dogs, and this study aimed to find its presence in dog blood samples while exploring its genetic diversity.
- Out of 400 samples, TTCaV was detected in 28 cases, indicating a prevalence of 7%, with five unique strains identified that are closely related to known strains.
- The genetic analysis showed high sequence similarity among the strains, suggesting significant genetic diversity, and revealed that TTCaV can co-infect with canine parvovirus in dogs in China, prompting the need for further studies on its effects.
Article Abstract
The Torque teno canis virus (TTCaV) is a small virus with circular single-stranded DNA that has been reported to cause infections in dogs. The present study aimed to identify the presence of TTCaV in blood samples obtained from domestic dogs, and examine its diversity and evolution of the genomes. Five strains of TTCaV were detected, and the overall prevalence was found to be 7% (28/400). Phylogenetic analysis showed that the five genomes were closely clustered with the previously known Cf-TTV10 and LDL strains and formed a Thetatorque virus. Homology analysis of the whole genome showed a sequence identity of 94.6%-96.8% among the five genomes. The percent sequence similarity among the five complete genomes ranged from 95.3% to 97.4% and from 95.1% to 97% compared to the Cf-TTV10 and LDL strains respectively. The ORF1-encoded amino acid sequences showed 94.4%-97.2% identity among the five isolates. Our findings suggest that the TTCaV has a large genetic diversity and showed that TTCaV and canine parvovirus (CPV) co-infection exists in China. Further studies on the pathogenicity of TTCaV are required.
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| http://dx.doi.org/10.1016/j.jbiotec.2017.05.003 | DOI Listing |
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