Tuberculoid granuloma in a clinically normal looking skin.

Indian J Lepr

Department of Dermatology, B.H. Barrackpore.

Published: April 1988

A case of tuberculoid leprosy showing well defined tuberculoid granuloma in the skin without any morphological changes is reported.

Download full-text PDF

Source

Publication Analysis

Top Keywords

tuberculoid granuloma
8
granuloma clinically
4
clinically normal
4
normal skin
4
skin case
4
case tuberculoid
4
tuberculoid leprosy
4
leprosy showing
4
showing well
4
well defined
4

Similar Publications

Cutaneous tuberculosis is a rare and often overlooked manifestation of tuberculosis, frequently leading to delays from onset to diagnosis. This case report describes the presentation of a 65-year-old male with an asymptomatic solitary plaque with silvery scales persisting for over five years, mimicking solitary plaque psoriasis. Despite intermittent treatment with a potent steroid and a combination of calcipotriol, the patient had only modest alleviation.

View Article and Find Full Text PDF

Cellular and molecular determinants of bacterial burden in leprosy granulomas revealed by single-cell multimodal omics.

EBioMedicine

October 2024

Hospital for Skin Diseases, Shandong First Medical University, Shandong, China; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Shandong, China. Electronic address:

Background: Which cell populations that determine the fate of bacteria in infectious granulomas remain unclear. Leprosy, a granulomatous disease with a strong genetic predisposition, caused by Mycobacterium leprae infection, exhibits distinct sub-types with varying bacterial load and is considered an outstanding disease model for studying host-pathogen interactions.

Methods: We performed single-cell RNA and immune repertoire sequencing on 11 healthy controls and 20 patients with leprosy, and integrated single-cell data with genome-wide genetic data on leprosy.

View Article and Find Full Text PDF

Leprosy as a cause of nasolacrimal duct obstruction.

Orbit

August 2024

Rhinology Service, Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.

Article Synopsis
  • - Leprosy, or Hansen disease, is an airborne illness characterized by symptoms like skin lesions, nerve damage, and eye issues, caused by specific bacteria.
  • - A patient with a history of tuberculoid leprosy developed severe tear duct issues four years after finishing treatment, leading to surgery to correct the blockage.
  • - Post-surgery, analysis revealed ongoing inflammation linked to the earlier leprosy infection, but the patient has been symptom-free for six months after the procedure.
View Article and Find Full Text PDF

Mucocutaneous manifestations of inflammatory bowel disease.

Ann Dermatol Venereol

September 2024

Dermatology Department, North Hospital, Assistance-Publique Hopitaux de Marseille, Aix-Marseille University, Marseille, France.

Article Synopsis
  • * Inflammatory bowel disease (IBD) is closely associated with various skin issues, categorized into four groups: reactive manifestations, Crohn's-specific lesions, nutritional deficiencies, and independent autoimmune/inflammatory skin diseases.
  • * Dermatologists play a role in treating adverse effects from IBD treatments, particularly concerning paradoxical reactions like psoriatic eruptions.
View Article and Find Full Text PDF
Article Synopsis
  • Non-sputum-based tests are crucial for diagnosing tuberculosis (TB) in people living with HIV (PWH), and the Kyn-to-Trp (K/T) plasma ratio may serve as a promising biomarker to predict TB disease in these patients on antiretroviral therapy (ART).
  • The study measured K/T ratios at three different time points (at diagnosis, 6 months before, and 6 months after) in PWH who developed TB, revealing significantly higher ratios at diagnosis compared to matched controls.
  • Following successful TB treatment, K/T ratios significantly dropped, but they increased in cases of treatment failure, suggesting the ratio could be useful for monitoring TB treatment in PWH, pending further validation studies.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!