A case of tuberculoid leprosy showing well defined tuberculoid granuloma in the skin without any morphological changes is reported.
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Cureus
September 2024
Faculty of Medicine, University of Ruhuna, Galle, LKA.
Cutaneous tuberculosis is a rare and often overlooked manifestation of tuberculosis, frequently leading to delays from onset to diagnosis. This case report describes the presentation of a 65-year-old male with an asymptomatic solitary plaque with silvery scales persisting for over five years, mimicking solitary plaque psoriasis. Despite intermittent treatment with a potent steroid and a combination of calcipotriol, the patient had only modest alleviation.
View Article and Find Full Text PDFEBioMedicine
October 2024
Hospital for Skin Diseases, Shandong First Medical University, Shandong, China; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Shandong, China. Electronic address:
Background: Which cell populations that determine the fate of bacteria in infectious granulomas remain unclear. Leprosy, a granulomatous disease with a strong genetic predisposition, caused by Mycobacterium leprae infection, exhibits distinct sub-types with varying bacterial load and is considered an outstanding disease model for studying host-pathogen interactions.
Methods: We performed single-cell RNA and immune repertoire sequencing on 11 healthy controls and 20 patients with leprosy, and integrated single-cell data with genome-wide genetic data on leprosy.
Orbit
August 2024
Rhinology Service, Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
Ann Dermatol Venereol
September 2024
Dermatology Department, North Hospital, Assistance-Publique Hopitaux de Marseille, Aix-Marseille University, Marseille, France.
BMC Infect Dis
April 2024
Department of Global Health and Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centers Location University of Amsterdam, Amsterdam, The Netherlands.
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