AI Article Synopsis
- Six pregnane steroids were extracted from the octocoral Carijoa riisei, including a new compound called 15β-hydroxypregna-4,20-dien-3-one.
- The cytotoxic effects of these compounds were tested on eight human cancer cell lines using the SRB method.
- Among the tested compounds, 18-acetoxypregna-1,4,20-trien-3-one showed significant cytotoxicity across all cell lines, while two others displayed weak effects on a specific cell line (KB).
Article Abstract
Six pregnane steroids including one new compound namely 15β-hydroxypregna-4,20-dien-3-one (1), were isolated and structurally elucidated from the octocoral Carijoa riisei. The cytotoxic activity against a panel of eight human cancer cell lines of isolated compounds was also evaluated by SRB method. As the results, 18-acetoxypregna-1,4,20-trien-3-one (5) showed significant cytotoxicity against all the tested cell lines with the IC values from 22.29 ± 1.47 to 48.73 ± 3.93 μM, whereas 15β-acetoxypregna-1,4,20-trien-3-one (3) and 20R-acetoxypregna-1,4-dien-3-one (6) only exhibited weak effect on KB cell line with IC values of 93.62 ± 7.32 and 71.38 ± 5.45 μM, respectively.
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| http://dx.doi.org/10.1080/14786419.2017.1324964 | DOI Listing |
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