We report 2 cases of disseminated cryptococcosis with central nervous system involvement in patients with chronic lymphoid malignancies occurring within 1 month of starting on ibrutinib. Characteristically, in both cases, no inflammation was seen in the cerebrospinal fluid. Central nervous system mycoses should be considered as a potential complication of ibrutinib.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413986PMC
http://dx.doi.org/10.1093/ofid/ofw261DOI Listing

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