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Behavioral study of a rat model of migraine induced by CGRP. | LitMetric

Behavioral study of a rat model of migraine induced by CGRP.

Neurosci Lett

Department of Neurology, The Second Hospital of Jilin University, Changchun, Jilin, China. Electronic address:

Published: June 2017

AI Article Synopsis

  • Migraine is a complex and painful disorder linked to issues in the brain's blood vessel functioning, but the exact causes are still unclear and challenging to study in animals.* -
  • This study created a new rat model of migraine by injecting calcitonin gene-related peptide (CGRP) and observed various behaviors in the rats, revealing significant changes indicating migraine-like symptoms.* -
  • The research showed that the new rat model closely mimics the behaviors seen in human migraine patients, making it a valuable resource for understanding migraines and developing new treatments.*

Article Abstract

Migraine is a debilitating disorder characterized by recurrent headache arising from neurovascular dysfunction. Despite recent progress in migraine research, the exact mechanisms underpinning migraine are poorly understood. Furthermore, it is difficult to develop an animal model of migraine that resembles all symptoms of patients. In this study, we established a novel animal model of migraine induced by epidural injection of calcitonin gene-related peptide (CGRP), and examined climbing hutch behavior, facial-grooming behavior, body-grooming behavior, freezing behavior, resting behavior, and ipsilateral hindpaw facial grooming behavior of rats following CGRP injection. CGRP significantly reduced climbing hutch behavior, and face-grooming behavior, and increased immobile behavior. We also found that the P15 and P85 percentile range of behavioral data exhibited a high positive rate (83.3%) for establishing the model with less false positive rate. Our results verified that the rat model of migraine induced by CGRP featured many behaviors of migraine patients demonstrated during migraine attacks. Our findings suggest that this new model can be a useful tool for understanding the pathophysiology of migraine and studying novel therapeutic strategies for the treatment of migraine.

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Source
http://dx.doi.org/10.1016/j.neulet.2017.04.059DOI Listing

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