AI Article Synopsis
- The study aimed to assess a Kevlar®-based prosthetic ligament as a synthetic graft for the anterior cruciate ligament (ACL) in a rabbit model, analyzing clinical, biomechanical, and morphological aspects.
- A total of 27 rabbit knees were divided into three groups (control, ACL excision, and ACL replacement with Kevlar®), and evaluations were conducted at 6, 12, and 18 weeks post-surgery.
- Results indicated that the Kevlar® prosthesis improved knee stability compared to ACL excision and had comparable displacement to the control group, with favorable histological adaptation observed, supporting further research on artificial ACL prostheses.
Article Abstract
Background: The aim of this study was to evaluate the clinical, biomechanical and morphological characteristics of a Kevlar®-based prosthetic ligament as a synthetic graft of the anterior cruciate ligament (ACL) in an experimental animal model in rabbits.
Methods: A total of 27 knees of rabbits randomly divided into 3 groups (control, ACL excision and ACL replacement with a Kevlar® prosthesis) were analyzed using clinical, biomechanical and morphological tests at 6, 12 and 18 weeks postprocedure.
Results: The mean displacement in mechanical testing was 0.73 ± 0.06 mm, 1.58 ± 0.19 mm and 0.94 ± 0.20 mm for the control, ACL excision and ACL replacement with synthetic prosthesis groups, respectively. The results showed an improvement in the stability of the knee with the use of the Kevlar® synthetic prosthesis in the biomechanical testing (p<0.05) compared with rabbits that underwent ACL excision, in addition to displacements that were larger but comparable to that in the control group (p>0.05), between the replacement group and the control group. The histological study revealed a good morphological adaptation of the synthetic material to the knee.
Conclusions: This study proposes a new animal model for the placement and evaluation of Kevlar®-based synthetic ACL implants. The studied prosthesis showed promising behavior in the clinical and biomechanical tests and in the histological analysis. This study lays the foundation for further basic and clinical studies of artificial ACL prostheses using this material.
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| http://dx.doi.org/10.5301/jabfm.5000353 | DOI Listing |
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