AI Article Synopsis
- Colonization of preterm infants' gut and skin starts in the womb, shaped by factors like gestational age and environment.
- The microbiota composition affects immune responses, potentially impacting the risk of serious conditions such as necrotizing enterocolitis and sepsis.
- Modifying microbiota to lower disease risk is particularly important for extremely preterm infants, who are evolutionarily new.
Article Abstract
Colonization of the extremely preterm infant's gastrointestinal tract and skin begins in utero and is influenced by a variety of factors, the most important including gestational age and environmental exposures. The composition of the intestinal and skin microbiota influences the developing innate and adaptive immune responses with short-term and long-term consequences including altered risks for developing necrotizing enterocolitis, sepsis, and a wide variety of microbe-related diseases of children and adults. Alteration of the composition of the microbiota to decrease disease risk is particularly appealing for this ultra-high-risk cohort that is brand new from an evolutionary standpoint.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361543 | PMC |
| http://dx.doi.org/10.1016/j.clp.2017.01.005 | DOI Listing |
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