The authors report the biological synthesis of zinc oxide nanoparticles (ZnO-NPs) from the petals extract of L. (rose). Its efficacy was evaluated against two dermatophytes: namely: and which cause onychomycosis. The activity of antibiotics against the tested dermatophytes was enhanced, when evaluated in combination with ZnO-NPs. The synthesised ZnO-NPs were preliminary detected by using ultraviolet UV visible spectroscopy, which showed specific absorbance. The ZnO-NPs were further characterised by nanoparticle tracking analysis (NTA), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction and Zetasizer. Moreover, nanoparticles containing nail paint (nanopaint) was formulated and its antifungal activity was also assessed against and . ZnO-NPs and formulated nanopaint containing ZnO-NPs, both showed significant antifungal activity. The maximum activity was noted against and lesser against Minimum inhibitory concentration of ZnO-NPs was also determined against the dermatophytes causing onychomycosis infection. ZnO-NPs can be utilised as a potential antifungal agent for the treatment of onychomycosis after more experimental trials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8676562 | PMC |
| http://dx.doi.org/10.1049/iet-nbt.2016.0003 | DOI Listing |
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