AI Article Synopsis
- The study focused on the effectiveness and safety of salvage radiotherapy for treating solitary metachronous bone metastasis (SMBM) in breast cancer patients.
- Researchers evaluated 17 patients who received this treatment with a median radiation dose of 50 Gy and found that local recurrence was low, occurring in only 2 patients over an average follow-up of 40 months.
- The results indicated high overall survival rates (93%) and low toxicity, suggesting that salvage radiotherapy is a promising option for managing SMBM in breast cancer.
Article Abstract
Aim: We assessed the efficacy and toxicity of salvage radiotherapy for solitary metachronous bone metastasis (SMBM) in patients with breast cancer.
Patients And Methods: We retrospectively analyzed 17 patients with SMBM who were treated with salvage radiotherapy. First failure was detected as SMBM in all patients. Salvage radiotherapy using three-dimensional treatment planning was performed at a median total dose of 50 Gy. Median daily dose was 2.0 Gy.
Results: Median follow-up was 40 months. Local recurrence of SMBM was noted in only two patients. The 3-year overall survival, progression-free survival, and local control rates were 93%, 51%, and 85%, respectively. Median overall and progression-free survival were 74 and 30 months, respectively. Toxicities were mild, and bone fractures were not observed.
Conclusion: Salvage radiotherapy for SMBM was able to achieve higher local control rates without severe toxicity, as well as to provide longer progression-free survival; therefore, this may be an effective modality.
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| http://dx.doi.org/10.21873/anticanres.11601 | DOI Listing |
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