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Chronic DON exposure and acute LPS challenge: effects on porcine liver morphology and function. | LitMetric

AI Article Synopsis

  • - The study investigated how chronic exposure to deoxynivalenol (DON) affects liver health in young pigs exposed to lipopolysaccharide (LPS) stress, using a 4-week feeding trial with DON-contaminated diets.
  • - Results showed that LPS administration caused significant liver issues, including hemorrhage and increased liver weights, but chronic DON intake alone did not alter liver morphology.
  • - While LPS stress impacted certain liver function indicators (like bilirubin levels), mitochondrial respiration and calcium accumulation in the liver remained unaffected by either DON exposure or LPS treatment, highlighting that DON's effects on liver function occur under stress conditions rather than through direct changes to liver structure.

Article Abstract

The aim of the present study was to examine the role of chronic deoxynivalenol (DON) exposition on the liver morphology and function in combination with pre- and post-hepatic lipopolysaccharide (LPS) stress in young pigs fed for 4 weeks with a DON-contaminated diet (4.59 mg/kg feed). At the end of the experiment, LPS (7.5 μg/kg BW) was administered for 1 h pre-hepatically (Vena portae hepatis) or post-hepatically (Vena jugularis). Liver morphology was macroscopically checked and showed haemorrhage in all LPS groups, significantly higher relative liver weights, accompanied by marked oedema in the gallbladder wall. Histological changes were judged by a modified histology activity index (HAI). Liver HAI score was significantly increased in all LPS groups compared to placebo, primarily due to neutrophil infiltration and haemorrhage. DON feed alone was without effect on the liver HAI. Liver function was characterized by (i) hepatic biochemical markers, (ii) mitochondrial respiration and (iii) Ca accumulation capacity of isolated mitochondria. Clinical chemical parameters characterizing liver function were initially (<3 h) slightly influenced by LPS. After 3 h, bilirubin and alkaline phosphatase were increased significantly, in DON-fed, jugular-infused LPS group. Respiration and Ca accumulation capacity of isolated liver mitochondria was not impaired by chronic DON exposure, acute LPS challenge or combined treatments. DON-contaminated feed did not change macroscopy and histology of the liver, but modified the function under LPS stress. The different function was not linked to modifications of liver mitochondria.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511606PMC
http://dx.doi.org/10.1007/s12550-017-0279-9DOI Listing

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