Stimulated Raman scattering of polymer nanoparticles for multiplexed live-cell imaging.

Chem Commun (Camb)

Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA.

Published: June 2017

A novel nanoparticle-based imaging strategy is introduced that couples biocompatible organic nanoparticles and stimulated Raman scattering (SRS) microscopy. Polymer nanoparticles with vibrational labels incorporated were readily prepared for multi-color SRS imaging with excellent photo-stability. The Raman-active polymer dots are nontoxic, rapidly enter various cell types, and are applied in multiplexed cell-type sorting.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623589PMC
http://dx.doi.org/10.1039/c7cc01860fDOI Listing

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