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SYD985, a novel duocarmycin-based HER2-targeting antibody-drug conjugate, shows promising antitumor activity in epithelial ovarian carcinoma with HER2/Neu expression. | LitMetric

AI Article Synopsis

  • Epithelial ovarian cancer (EOC) is a serious disease with varied levels of HER2/neu receptor expression, affecting treatment methods; SYD985 is a new antibody-drug conjugate designed to target this receptor.
  • In tests using EOC cell lines, SYD985 showed significantly higher cytotoxicity compared to trastuzumab emtansine (T-DM1) when peripheral blood lymphocytes were absent and was effective in killing nearby cancer cells with low or no HER2/neu expression.
  • Overall, SYD985 demonstrated superior effectiveness in EOC treatment in animal models, particularly for tumors expressing moderate to low levels of HER2/neu, making it a promising alternative to T-DM1. *

Article Abstract

Background: Epithelial ovarian cancer (EOC) is an aggressive and heterogeneous disease. <10% of EOC demonstrate HER2/neu 3+ receptor over-expression. However, moderate to low (i.e., 2+ and 1+) HER2/neu expression is reported in up to 50% of EOC. The objective of this study was to compare the anti-tumor activity of SYD985, a novel HER2-targeting antibody-drug conjugate (ADC), to trastuzumab emtansine (T-DM1) in EOC models with differential HER2/neu expression.

Methods: The cytotoxicity of SYD985 and T-DM1 was evaluated using ten primary EOC cell lines with 0/1+, 2+, and 3+ HER2/neu expression in antibody-dependent cellular cytotoxicity (ADCC), proliferation, viability and bystander killing experiments. Finally, the in vivo activity of SYD985 and T-DM1 was also studied in ovarian cancer xenografts.

Results: SYD985 and T-DM1 induced similar ADCC in the presence of peripheral blood lymphocytes (PBL) against EOC cell lines with differential HER2/neu expression. In contrast, SYD985 was 3 to 42 fold more cytotoxic in the absence of PBL when compared to T-DM1 (p<0.0001). Unlike T-DM1, SYD985 induced efficient bystander killing of HER2/neu 0/1+ tumor cells when admixed with HER2/neu 3+ EOC cells. In vivo studies confirmed that SYD985 is significantly more active than T-DM1 against HER2/neu 3+ EOC xenografts.

Conclusions: SYD985 is a novel ADC with remarkable activity against EOC with strong (3+) as well as moderate to low (i.e., 2+ and 1+) HER2/neu expression. SYD985 is more potent than T-DM1 in comparative experiments and unlike T-DM1, it is active against EOC demonstrating moderate/low or heterogeneous HER2/neu expression.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533304PMC
http://dx.doi.org/10.1016/j.ygyno.2017.04.023DOI Listing

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