AI Article Synopsis
- Lung function decline is a key factor in the development of Chronic Obstructive Pulmonary Disease (COPD), based on data from two surveys of 2026 adults in Latin America.
- The study found that mean annual post BronchoDilator (postBD) FEV1 decline was similar in individuals with and without COPD, influenced by factors like baseline lung function and smoking habits.
- Overall, the decline in lung function was linked to higher initial lung capacity, older age, and respiratory issues, being particularly pronounced in smokers and elderly patients.
Article Abstract
Background: Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD).
Methods: We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5-9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV1 decline in mL/y, as %predicted/y (%P/y) and % of baseline/y (%B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models.
Results: Expressed in ml/y, the mean annual postBD FEV1 decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bronchodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or ≥2 respiratory exacerbations in the previous year, and in men with asthma.
Conclusions: Lung function decline in a population-based cohort did not differ in obstructed and non-obstructed individuals, it was proportional to baseline FEV1, and was higher in smokers, elderly, and women with respiratory symptoms.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417635 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177032 | PLOS |
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