Background: The development of novel highly efficacious fungicides that lack cross-resistance is extremely desirable. Fenpicoxamid (Inatreq™ active) possesses these characteristics and is a member of a novel picolinamide class of fungicides derived from the antifungal natural product UK-2A.
Results: Fenpicoxamid strongly inhibited in vitro growth of several ascomycete fungi, including Zymoseptoria tritici (EC , 0.051 mg L ). Fenpicoxamid is converted by Z. tritici to UK-2A, a 15-fold stronger inhibitor of Z. tritici growth (EC , 0.0033 mg L ). Strong fungicidal activity of fenpicoxamid against driver cereal diseases was confirmed in greenhouse tests, where activity on Z. tritici and Puccinia triticina matched that of fluxapyroxad. Due to its novel target site (Q site of the respiratory cyt bc1 complex) for the cereals market, fenpicoxamid is not cross-resistant to Z. tritici isolates resistant to strobilurin and/or azole fungicides. Across multiple European field trials Z. tritici was strongly controlled (mean, 82%) by 100 g as ha applications of fenpicoxamid, which demonstrated excellent residual activity.
Conclusions: The novel chemistry and biochemical target site of fenpicoxamid as well as its lack of cross-resistance and strong efficacy against Z. tritici and other pathogens highlight the importance of fenpicoxamid as a new tool for controlling plant pathogenic fungi. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599960 | PMC |
http://dx.doi.org/10.1002/ps.4588 | DOI Listing |
ACS Synth Biol
November 2024
Crop Health R&D, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, Indiana 46268, United States.
J Comput Aided Mol Des
April 2024
Corteva Agriscience, Indianapolis, IN, 46268, USA.
J Agric Food Chem
February 2024
National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health of Ministry of Science and Technology, Central China Normal University, Wuhan 430079, People's Republic of China.
Picolinamide fungicides, structurally related to UK-2A and antimycin-A, bind into the Qi-site in the complex. However, the detailed binding mode of picolinamide fungicides remains unknown. In the present study, antimycin-A and UK-2A were selected to study the binding mode of picolinamide inhibitors with four protonation states in the Qi-site by integrating molecular dynamics simulation, molecular docking, and molecular mechanics Generalized Born surface area (MM/GBSA) calculations.
View Article and Find Full Text PDFMicromachines (Basel)
December 2023
Department of Nutrition and Dietetics, Faculty of Health Sciences, Hasan Kalyoncu University, Gaziantep 27000, Turkey.
This research attempt involved the development and utilization of a newly designed surface plasmon resonance (SPR) sensor which incorporated sulfur-doped graphitic carbon nitride (S-g-CN) as the molecular imprinting material. The primary objective was to employ this sensor for the quantitative analysis of Fenpicoxamid (FEN) in rice samples. The synthesis of S-g-CN with excellent purity was achieved using the thermal poly-condensation approach, which adheres to the principles of green chemistry.
View Article and Find Full Text PDFFront Plant Sci
January 2023
Lithuanian Research Centre for Agriculture and Forestry, Institute of Agriculture, Akademija, Lithuania.
causes the disease known as septoria leaf blotch in winter wheat and is a major factor in yield loss worldwide. Farmers are inclined to use fungicides to protect their crops; however, the efficacy of these measures is rapidly decreasing due to the natural mechanisms of mutation emergence in pathogen populations. Increasing fungicide resistance is being recorded worldwide, therefore, screening of the current situation in Lithuania is essential to determine the subsequent steps of crop protection strategies.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!