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Splicing of Ezh1 gets muscle out of stressful situations.
Nat Struct Mol Biol
May 2017
Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, and the Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
A lncRNA regulates alternative splicing via establishment of a splicing-specific chromatin signature.
Nat Struct Mol Biol
May 2015
ATIP-AVENIR team, Institute of Human Genetics, CNRS UPR 1142, Montpellier, France.
Alternative pre-mRNA splicing is a highly cell type-specific process essential to generating protein diversity. However, the mechanisms responsible for the establishment and maintenance of heritable cell-specific alternative-splicing programs are poorly understood. Recent observations point to a role of histone modifications in the regulation of alternative splicing.
View Article and Find Full Text PDFFunctional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression.
Epigenetics Chromatin
February 2013
Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, MN, 55905, USA.
Background: Histone methyltransferase enhancer of zeste homologue 2 (EZH2) forms an obligate repressive complex with suppressor of zeste 12 and embryonic ectoderm development, which is thought, along with EZH1, to be primarily responsible for mediating Polycomb-dependent gene silencing. Polycomb-mediated repression influences gene expression across the entire gamut of biological processes, including development, differentiation and cellular proliferation. Deregulation of EZH2 expression is implicated in numerous complex human diseases.
View Article and Find Full Text PDFCharacterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1.
Genomics
October 1996
Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor 48109, USA.
Recent transcription mapping efforts within chromosome 17q21 have led to the identification of a human homolog of the Drosophila gene Enhancer of zeste, E(z). A member of the Polycomb group (Pc-G) of proteins, Drosophila E(z) acts as a negative regulator of the segment identity genes of the Antennapedia and Bithorax complexes. Here we report the full-length protein coding sequence of human EZH1 (Enhancer of zeste homolog 1) and compare the respective protein sequences in both species.
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