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Incidence and Risk Factors for Amiodarone-Induced Thyroid Dysfunction: A Nationwide Retrospective Cohort Study.
Am J Cardiovasc Drugs
January 2025
Division of Cardiology, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
Background: Amiodarone is an effective anti-arrhythmic drug; however, it is frequently associated with thyroid dysfunction. The aim of this study was to investigate the incidence and risk factor of amiodarone-induced dysfunction in an iodine-sufficient area.
Methods: This retrospective cohort study included 27,023 consecutive patients treated with amiodarone for arrhythmia, using the Korean National Health Insurance database.
Gynaecomastia Revealing Amiodarone-Induced Hypergonadotropic Hypogonadism: An Overlooked Complication?
Eur J Case Rep Intern Med
October 2024
Department of Endocrinology, CHU UCL Namur - Site Godinne, Université Catholique de Louvain, Yvoir, Belgium.
Article Synopsis
- A case study discusses primary hypogonadism caused by prolonged use of amiodarone, a medication known for multiple side effects.
- The patient, a 57-year-old man, experienced testicular pain, gynaecomastia, and decreased libido, ultimately diagnosed with hypergonadotropic hypogonadism and confirmed testicular atrophy.
- The findings emphasize the need for careful monitoring of patients on amiodarone to detect signs of testicular dysfunction early, ensuring appropriate treatment for hypogonadism.
Amiodarone Therapy: Updated Practical Insights.
J Clin Med
October 2024
Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Article Synopsis
- Amiodarone is a highly effective antiarrhythmic drug used to treat conditions like atrial fibrillation and ventricular arrhythmias, functioning across all four classes of antiarrhythmics.
- It has a long half-life and complex pharmacokinetics, which can lead to prolonged effects even after stopping the medication, making regular monitoring for side effects like thyroid issues and lung damage essential.
- This paper aims to offer a detailed review of amiodarone's uses, dosing guidelines, interactions with other medications, and necessary monitoring practices.
Enhanced Differentiation of Amiodarone-Induced Thyrotoxicosis Types Using Semi-Quantitative 99mTc-MIBI Uptake Analysis: A Pilot Study.
Med Sci Monit
September 2024
Department of Nuclear Medicine, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Article Synopsis
- The study investigates the effectiveness of technetium-99m (99mTc)-labelled Methoxy-2-Isobutylisonitrile (MIBI) in diagnosing amiodarone-induced thyrotoxicosis (AIT) through various medical tests, including thyroid scintigraphy and ultrasonography.
- It included 36 AIT patients who underwent multiple analyses, and results showed that semi-quantitative MIBI analysis was more effective in differentiating between AIT subtypes compared to visual analysis.
- The findings suggest that while visual analysis is helpful, semi-quantitative methods provide improved accuracy, indicating the need for larger studies to standardize diagnostic approaches.
Refractory amiodarone-induced thyrotoxicosis requiring adjunctive cholestyramine treatment.
BMJ Case Rep
September 2024
Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
Amiodarone is an antiarrhythmic drug which may be associated with thyroid dysfunction. Type I amiodarone-induced thyrotoxicosis (AIT) is treated with thionamides and type II AIT is treated with glucocorticoids. Combined therapy is used in mixed or indeterminate forms.
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