AI Article Synopsis
- Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer, and this study explores the therapeutic potential of alpinumisoflavone (AIF), a natural flavonoid compound.
- AIF was found to increase the levels of miR-101, which has anti-tumor effects on ccRCC by targeting RLIP76, indicating a novel approach for treatment.
- The research suggests that AIF could be a promising agent in ccRCC therapy by inhibiting Akt signaling and enhancing miR-101 expression.
Article Abstract
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. The present study is aimed to investigate the role of alpinumisoflavone (AIF), a naturally occurring flavonoid compound, in ccRCC and the underlying mechanism. In this study, miR-101 has been identified as a novel therapeutic target, which exerts anti-tumor effect on ccRCC by directly targeting RLIP76. Moreover, our results showed that AIF was able to increase the expression of miR-101 by suppressing Akt signalling. Our findings in this study provided experimental evidence that AIF has the potential to be used as an agent in the treatment of ccRCC.
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