Cancer of unknown primary (CUP) is a well-known entity that can present in a multitude of clinical presentations. Based on the extent and organ of involvement, the presentation will be varied. For instance, patients presenting with axillary lymphadenopathy would lead toward a primary breast cancer, whereas patients presenting with abdominal distention due to ascites would tend toward a gastrointestinal origin. We present a case of a 73-year-old female who presented with an abdominal wall mass; on laparoscopy, she was found to have a spigelian hernia due to an omental metastatic lesion from a CUP.
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http://dx.doi.org/10.1093/jscr/rjw218 | DOI Listing |
JAMA Netw Open
January 2025
Division of Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, Massachusetts.
Importance: CHEK2 pathogenic and likely pathogenic variants (PVs) are common, and low-risk (LR) variants, p.I157T, p.S428F, and p.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Medical Oncology, The Ottawa Hospital Cancer Centre, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada.
Importance: Evolving breast cancer treatments have led to improved outcomes but carry a substantial financial burden. The association of treatment costs with the cost-effectiveness of screening mammography is unknown.
Objective: To determine the cost-effectiveness of population-based breast cancer screening in the context of current treatment standards.
Acta Obstet Gynecol Scand
January 2025
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Introduction: Diagnostic work-up of older women with a positive cervical cancer screening test is often challenging due to incomplete visualization of the transformation zone. To reduce the risk of missing disease, a diagnostic cervical excision may be performed. However, little is known on treatment efficacy and post-treatment surveillance for older women.
View Article and Find Full Text PDFBiosci Rep
January 2025
Tata Institute of Fundamental Research, Bangalore, India.
The tumor suppressor PALB2 is a key player in the Homologous Recombination (HR) pathway, functionally connecting BRCA proteins at the DNA damage site. PALB2 forms homodimers via its coiled-coil domain, and during HR, it forms a heterodimeric complex with BRCA1 using the same domain. However, the structural details of the human PALB2 coiled-coil domain are unknown.
View Article and Find Full Text PDFCan J Vet Res
January 2025
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Auburn University, 1220 Wire Road, Auburn, Alabama 36849-5540, USA.
Sentinel lymph node (SLN) mapping has been shown to be important for staging in dogs with mast cell tumors (MCTs). Despite this, many patients are referred to an oncologist after surgical intervention has been carried out. It is unknown whether lymphatic drainage patterns are altered by surgery and whether postoperative SLN mapping can be reliably conducted.
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