AI Article Synopsis
- Chorioamnionitis (CAM) increases the risk of bronchopulmonary dysplasia (BPD) in premature infants, highlighting its significance in infant health.
- The study measured levels of interleukin 6 (IL-6), Krebs von den Lungen 6 (KL-6), and transforming growth factor β (TGF-β) in the amniotic fluid to assess inflammation and lung damage.
- Results indicated that higher levels of these markers were linked to more severe CAM and a greater likelihood of developing BPD in affected infants.
Article Abstract
Background: Chorioamnionitis (CAM) is an important risk factor for the development of bronchopulmonary dysplasia (BPD) in preterm infants.
Objectives: To evaluate the effects of CAM on the development of BPD using interleukin 6 (IL-6), Krebs von den Lungen 6 (KL-6), and transforming growth factor β (TGF-β) in the amniotic fluid as markers for inflammation, lung injury, and fibrosis/remodeling, respectively.
Methods: Amniotic fluid concentrations of IL-6, KL-6, and TGF-β were measured with enzyme-linked immunosorbent assay or electro-chemiluminescence immunoassay.
Results: Of the 36 preterm infants, 18 were exposed to histologically confirmed CAM. Of these, 12 were later diagnosed as having BPD. The IL-6, KL-6, and TGF-β levels in the amniotic fluid significantly increased with increasing histologic severity of CAM. Moreover, these markers were higher in the BPD group with histologic CAM than those without.
Conclusions: Our study suggests that CAM is likely to induce inflammatory, injury, and remodeling processes in the fetal lung.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398658 | PMC |
| http://dx.doi.org/10.1177/1179066017696076 | DOI Listing |
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