AI Article Synopsis
- Crohn's disease (CD) is an inflammatory bowel disease influenced by genetics, gut microbiome, and environmental factors like diet.
- Exclusive enteral nutrition (EEN) can induce remission in up to 80% of CD patients, though its exact mechanism of action is still unclear.
- The review discusses how EEN affects the gut microbiome in CD patients, which may improve understanding of the disease and help develop new dietary therapies.
Article Abstract
Crohn's disease (CD), a form of inflammatory bowel disease (IBD), is thought to arise from a complex interaction of genetics, the gut microbiome, and environmental factors, such as diet. There is clear evidence that dietary intervention is successful in the treatment of CD-exclusive enteral nutrition (EEN) is able to induce remission in up to 80% of CD patients. While the mechanism of action of EEN is not clear, EEN is known to cause profound changes in the gut microbiome. Understanding how EEN modifies the gut microbiome to induce remission could provide insight into CD etiopathogenesis and aid the development of microbiome-targeted interventions to guide ongoing dietary therapy to sustain remission. This review includes current literature on changes in composition and function of the gut microbiome associated with EEN treatment in CD patients.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452177 | PMC |
| http://dx.doi.org/10.3390/nu9050447 | DOI Listing |
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