AI Article Synopsis
- Mechanical life support for respiratory and cardiac issues is on the rise, requiring anticoagulation to prevent clotting.
- Unfractioned heparin is usually the standard treatment, but it can lead to a rare immunologic reaction called heparin-induced thrombocytopenia (HIT).
- A case example is provided of a neonate with HIT who was successfully treated with fondaparinux while on extracorporeal life support.
Article Abstract
The utilization of mechanical life support due to respiratory insufficiency and serious cardiac pathologies have been increasing. Anticoagulation to prevent clot formation is mandatory and unfractioned heparin is the standard therapy in use. But rarely heparin induced thrombocytopenia (HIT) might develop as an immunologic side effect of heparin. Development of thrombosis as a result of HIT increases the morbidity and mortality. We present a neonate with HIT treated successfully with fondaparinux under extracorporeal life support.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394489 | PMC |
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