Objectives: Spinal cord stimulation (SCS) remains poorly efficient at reducing back pain in failed back surgery syndrome (FBSS) patients. We aimed at determining whether a new multicolumn lead SCS technique was efficient at durably reducing their leg (LP) and back (BP) pain.
Materials And Methods: Sixty-two consecutive refractory FBSS patients received multicolumn SCS. Visual analogue scale (VAS) self-evaluation of BP, LP, and limitation of daily activity (LAD) were recorded preoperatively and at 2, 6, 12, 24, and 36 months after surgery. Quality of sleep and use of concomitant medications were also recorded.
Results: Complete datasets were obtained in 29 patients. BP (median VAS [25-75 centiles]) significantly decreased from 9 (8.5-10) preoperatively, to 3 (3-4) at short-term follow-up (2 months), and rose up to 5 (4-5) at 36 months. LP evolved from 7 (6-8) preoperatively, to 2.5 (2-3) at short-term follow-up, and 3 (2-3) at 36 months. Correspondingly, LAD VAS was 8 (8-9) preoperatively, and decreased to stable values of 3 (3-4) during the follow-up period. Quality of sleep also improved, with 72% of patients reporting poor sleep preoperatively to 0-7% in the follow-up period until 36 months. The percentages of patients regularly taking analgesic and/or co-analgesic medications decreased from 100% preoperatively to 8, 4, 12, 19, and 19%.
Conclusion: Multicolumn lead SCS in FBSS patients significantly improve BP, LP, quality of life, and medication consumption for at least 36 months. A classical placebo effect cannot account for long-term improvements of such magnitude.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/ner.12603 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Advanced control strategies for continuous capture of monoclonal antibodies based upon biolayer interferometry.
Biotechnol Bioeng
February 2024
Sartorius, Corporate Research, Göttingen, Germany.
The semi and fully continuous production of monoclonal antibodies (mAbs) has been gaining traction as a lower cost, and efficient production of mAbs to broaden patient access. To be truly flexible and adaptive to process demands, the industry has lacked sufficient advanced control strategies. The variation of the upstream product concentration typically cannot be handled by the downstream capture step, which is configured for a constant feed concentration and fixed binding capacity.
View Article and Find Full Text PDFAnimal Feasibility Study of a Novel Spinal Cord Stimulation Multicolumn Lead (Heron Lead).
Discov Med
August 2023
Department of Anesthesiology, University of Wisconsin, Madison, WI 53792, USA.
Background: Currently available spinal cord stimulation paddle leads require a laminectomy, limiting the types of clinicians who can implant and increasing the risk of complications. Recently, WISE S.r.
View Article and Find Full Text PDF"Neuro-Fiber Mapping": An Original Concept of Spinal Cord Neural Network Spatial Targeting Using Live Electrostimulation Mapping to (Re-)Explore the Conus Medullaris Anatomy.
J Clin Med
February 2023
PRISMATICS Laboratory (Predictive Research in Spine/Neuromodulation Management and Thoracic Innovation/Cardiac Surgery), Poitiers University Hospital, 86000 Poitiers, France.
Spinal cord (SC) anatomy is often assimilated to a morphologically encapsulated neural entity, but its functional anatomy remains only partially understood. We hypothesized that it could be possible to re-explore SC neural networks by performing live electrostimulation mapping, based on "super-selective" spinal cord stimulation (SCS), originally designed as a therapeutical tool to address chronic refractory pain. As a starting point, we initiated a systematic SCS lead programming approach using live electrostimulation mapping on a chronic refractory perineal pain patient, previously implanted with multicolumn SCS at the level of the conus medullaris (T12-L1).
View Article and Find Full Text PDFProceedings of the 2019 Viral Clearance Symposium, Session 3: Continuous Processing.
PDA J Pharm Sci Technol
August 2022
Process Virology Purification Development, Genentech, a Member of the Roche Group 1 DNA Way, South San Francisco, CA 94080.
Successful implementation of continuous processing requires an understanding of how to incorporate viral testing and clearance/inactivation into the process via representative small-scale models. Following the lead of the 2017 Viral Clearance Symposium, a session was devoted to understanding the impact of continuous process conditions on viral safety, how to design process for continuous viral inactivation/removal, and how to leverage existing batch data for a continuous process. In this session, there was a presentation investigating the impact of extended continuous cell culture on the production of endogenous retroviral-like particles, two presentations on the robustness of multicolumn capture chromatography and continuous viral filtration for clearance of viral particles, two talks on leveraging well-characterized batch processing data and scientific knowledge to demonstrate viral clearance capabilities of continuous processing, and finally two presentations related to process designs for continuous viral inactivation.
View Article and Find Full Text PDFHow Should we Use Multicolumn Spinal Cord Stimulation to Optimize Back Pain Spatial Neural Targeting? A Prospective, Multicenter, Randomized, Double-Blind, Controlled Trial (ESTIMET Study).
Neuromodulation
January 2021
Department of Neurosurgery, Spine & Neurostimulation Unit, Poitiers University Hospital, Poitiers, France.
Background: Recent studies have highlighted multicolumn spinal cord stimulation (SCS) efficacy, hypothesizing that optimized spatial neural targeting provided by new-generation SCS lead design or its multicolumn programming abilities could represent an opportunity to better address chronic back pain (BP).
Objective: To compare multicolumn vs. monocolumn programming on clinical outcomes of refractory postoperative chronic BP patients implanted with SCS using multicolumn surgical lead.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!